6 at 923 K). Our research results provide a strong theoretical basis for the experimental exploration of the TE properties of RbAgM, and help to promote further experimental verification.Herein, a simple and practical method for generating isoacenofuran, a new π-extended quinoidal building block, was developed. A three-step protocol involving double nucleophilic additions of alkynyllithiums to acene-2,3-dicarbaldehyde, mono-oxidation, and acid-promoted cyclization enables the generation of the target molecule, which is trapped by a dienophile to produce highly condensed acenequinones. Further transformations by double nucleophilic additions of alkynyllithium to hexacenequinone, followed by reductive aromatization, produce tetraalkynylhexacenes with a remarkably higher stability than that of the previously reported substituted hexacenes.A dual functional nanoprobe Pd-Q+@PDMS was proposed to simultaneously monitor Cl- and O2, leading to the determination of an average Cl- concentration of 85.7 ± 5.5 mM in lysosomes of HeLa cells. Mimicking ischemic conditions, the cells exhibited a luminescence change corresponding to a decreasing subcellular Cl- concentration.N-doped carbon dot (NCD)@COFBTT-Th nanosheets with strong dual-emission fluorescence are prepared by encapsulating NCDs into COFBTT-Th through amine-aldehyde dehydration condensation between benzotrithiophene tricarbaldehyde and terephthalic dihydrazide. The fluorescence of COFBTT-Th is enhanced because of fluorescence resonance energy transfer and the decrease of interlaminar accumulation and intramolecular rotation.For the first time, the molecular structure of 3-aminophthalimide has been determined by the gas electron diffraction (GED) method supported by a mass-spectrometric analysis of the gas phase and results of quantum-chemical computations up to coupled-cluster level of theory, CCSD(T). The semiexperimental equilibrium structure, rsee, has been derived from the GED data by taking into account harmonic and anharmonic vibrational corrections estimated from the quantum-chemical force field (up to cubic terms). High accuracy structures have been exploited for the observation of fine structural effects arising due the presence of the electron-donating amino group and the formation of a hydrogen bond. Natural bond orbital (NBO) analysis and quantum theory of atoms in molecules (QTAIM) have been applied to explain these effects.A novel ferrocene-linked metal-covalent organic polymer (MCOP-NFC) was synthesized through the Claisen-Schmidt condensation reaction of 1,1′-diacetyl ferrocene and tris(4-formylphenyl)amine. MCOP-NFC acts as a highly efficient artificial enzyme for mimicking peroxidase, and shows good stability in harsh chemical environments including strong bases and acids, and boiling water. Based on the peroxidase-like activity of MCOP-NFC, a highly sensitive dual channel detection method for hydrogen peroxide was developed. Anacardic Acid research buy For the colorimetric detection strategy, the limit of detection (LOD) reached 2.1 μM, while the limit of detection was found to be as low as 0.08 μM based on the electrochemical detection channel. This study offers a new strategy for the development of an enzyme mimetic on the basis of the covalent assembly of nanostructures, and the proposed electrochemical-colorimetric sensor for H2O2 detection has great potential for applications in biology and biomedicine.In situ monitoring of initial oxidation of GaAs surfaces was performed under (near-) realistic oxidizing environments, using ambient-pressure X-ray photoelectron spectroscopy (AP-XPS). The surface chemical states drastically change with time. The oxidation process at the sub-nano-meter-scale exhibits a significantly small activation energy, which can be regarded as a quasi-barrier-less oxidation.We synthesized Co2P nanoparticle encapsulated N-doped carbon nanocages through one-step carbonization-phosphidation of ZIF-67. As potassium ion battery (KIB, PIB) anodes, the Co2P@NCCs display state-of-the-art electrochemical performance, including the most favorable fast charge characteristics reported. The single-nanometer thick carbon cage yields rapid solid-state K-ion diffusion and prevents aggregation/pulverization of 40 nm cobalt phosphide.The development of biomaterial-based therapeutics to induce immune tolerance holds great promise for the treatment of autoimmune diseases, allergy, and graft rejection in transplantation. Historical approaches to treat these immunological challenges have primarily relied on systemic delivery of broadly-acting immunosuppressive agents that confer undesirable, off-target effects. The evolution and expansion of biomaterial platforms has proven to be a powerful tool in engineering immunotherapeutics and enabled a great diversity of novel and targeted approaches in engineering immune tolerance, with the potential to eliminate side effects associated with systemic, non-specific immunosuppressive approaches. In this review, we summarize the technological advances within three broad biomaterials-based strategies to engineering immune tolerance nonspecific tolerogenic agent delivery, antigen-specific tolerogenic therapy, and the emergent area of tolerogenic cell therapy.Graphdiyne (GDY), a novel two-dimensional (2D) carbon material with sp- and sp2-hybridized carbon atoms, has earned a lot of attention in recent years. Owing to its low reduction potential and highly conjugated electronic structure, it can be used as a reducing agent and stabilizer for the electroless deposition of highly dispersed Au nanoparticles. In this paper, we observe that exfoliated GDY (eGDY), the exfoliation of bulk GDY into single- or few-layered GDY in aqueous solution, can be used as an excellent substrate for the electroless deposition of very small Au nanoparticles to form a Au/eGDY nanocomposite that exhibits higher catalytic performance for the reduction of 4-nitrophenol. The higher catalytic performance is considered to arise from the high specific surface area of eGDY and the electroless deposition of active metal catalysts with eGDY as the support. Our results inspired the present investigation into the use of eGDY for the development of highly efficient catalysts.Hydrogels with antioxidant activity have shown to significantly improve the standard of care, because they promote efficient wound healing, i.e. regeneration. N-Acetylcysteine (NAC) is an antioxidant amino acid derivative that promotes complete tissue restoration. However, NAC has anticoagulant properties that may also hinder blood coagulation, which is crucial for hydrogels for wound healing applications. To take advantage of the regenerative activity of NAC while avoiding hampering the hemostasis stage during wound healing, we modified gelatin-NAC with the methacrylate-containing polymers 2-hydroxyethyl methacrylate (H) and poly(ethylene glycol) methyl ether methacrylate (P) to produce Gel-HP-NAC. These hydrogels clotted more blood and faster than Gel and Gel-NAC hydrogels, while maintaining fluid absorption properties adequate to promote wound healing. Similarly, there were more viable human skin fibroblasts after 10 days cultured in Gel-HP-NAC compared with Gel and Gel-NAC. A mouse full-thickness skin wound model demonstrated that Gel-HP-NAC hydrogels improved the wound healing process as compared to the untreated group as proved by the increased wound closure rates and re-epithelialization. Histology of the biopsied tissues indicated more organized collagen deposits on the wounds treated with either Gel-HP-NAC or Gel-NAC than untreated wounds. Our results show that modification of NAC-containing hydrogels through methacrylate-containing polymers improved their wound healing properties, including blood-clotting, and demonstrate the potential of Gel-HP-NAC hydrogels for wound treatment and tissue regeneration.Stimuli-responsive amphiphilic block copolymers have emerged as promising nanocarriers for enhancing site-specific and on-demand drug release in response to a range of stimuli such as pH, the presence of redox agents, and temperature. The formulation of amphiphilic block copolymers into polymeric drug-loaded nanoparticles is typically achieved by various methods (e.g. oil-in-water emulsion solvent evaporation, solid dispersion, microphase separation, dialysis or microfluidic separation). Despite much progress that has been made, there remain many challenges to overcome to produce reliable polymeric systems. The main drawbacks of the above methods are that they produce very low solid contents ( less then 1 wt%) and involve multiple-step procedures, thus limiting their scope. Recently, a new self-assembly methodology, polymerisation-induced self-assembly (PISA), has shown great promise in the production of polymer-derived particles using a straightforward one-pot approach, whilst facilitating high yield, scalability, and cost-effectiveness for pharmaceutical industry protocols. We therefore focus this review primarily on the most recent studies involved in the design and preparation of PISA-generated nano-objects which are responsive to specific stimuli, thus providing insight into how PISA may become an effective formulation strategy for the preparation of precisely tailored drug delivery systems and biomaterials, while some of the current challenges and limitations are also critically discussed.Platinum diselenide (PtSe2) has attracted huge attention due to its intriguing physical properties for both fundamental research and promising applications in electronics and optoelectronics. Here, we explored the optical properties of chemical vapor deposition-grown PtSe2 thin films with varied thicknesses via spectroscopic ellipsometry. The dielectric function was extracted by using a Lorentz model over the spectral range of 1.25-6.0 eV. We firstly ascribed the resonant energies, extracted from the Lorentz model, to different interband electronic transitions between valence bands and conduction bands in the Brillouin zone. A predicted exciton is observed at 2.18 eV for the monolayer and the corresponding exciton binding energy is 0.65 eV, in line with previous theoretical calculation and the measured absorption spectra. Additionally, the exciton peak shows a red shift with the increase of thickness, which is the consequence of strong interlayer interaction. These results enrich the fundamental understanding of PtSe2 and are conducive to its potential applications.The iodide/triiodide interaction with the dye on a semiconductor surface plays a significant role in understanding the dye-sensitized solar cells (DSSCs) mechanism and improving its efficiency. In the present study, density functional theory (DFT) calculations were used to determine the interaction between the complexed iodide redox couple with dye/TiO2 for the relevance of DSSCs. Three new metal-free organic dyes noted as D1Y, D2Y and D3Y, featured with D-π-A configuration were designed by varying functional groups on the donor moiety. We analyzed the structural and electronic properties of these dyes when standing alone and being adsorbed on the oxide surface with the iodide electrolyte. Of the designed dyes, the incorporation of a strong donor unit in D1Y and D2Y sensitizers in conjunction with iodide electrolytes on the TiO2 surface provides better adsorption and electronic properties in comparison to those from the dye alone on the TiO2 surface. Analysis of density of states (DOS) indicates that the introduction of a strong electron-donating group into the organic dye, mainly D1Y and D2Y with an iodide electrolyte on the surface remarkably upshifts the Fermi energy, thereby improving the efficiency of the DSSCs by an increase of the open-circuit voltage (Voc).