To characterize the clinical features associated with sinonasal complaints after maxillectomy with free flap reconstruction as well as propose a screening and treatment algorithm.

Retrospective review of patients who underwent maxillectomy and free flap reconstruction at a tertiary care center.

Fifty-eight patients were included, 25 (43.1%) of them had documented sinonasal complaints postoperatively. Eleven patients subsequently underwent revision surgery for sinonasal complaints. Among the 25 patients with sinonasal complaints, 22 patients (88.0%) had nasal crusting, 17 (68.0%) had nasal obstruction, 12 (48.0%) had rhinorrhea, 9 (36.0%) had facial pain or pressure, and 7 (28.0%) had foul odor. Twenty-two patients (88.0%) had multiple sinonasal complaints. There was a higher incidence of both sinonasal complaints and surgical intervention in patients who underwent adjuvant radiation, but this was not statistically significant (47.7% vs 28.6%, P= .235; 29.4% vs 7.1%, P= .265).

Sinonasal complaints are common following free flap reconstruction for a maxillectomy defect and should be screened for at postoperative visits, with early referral to a rhinologist for consideration of endoscopic sinus surgery. Nonsurgical treatment strategies include large-volume nasal saline irrigations, xylitol irrigations for persistent inflammatory symptoms, and culture-directed antibiotic irrigations for persistent infectious symptoms.

4 Laryngoscope, 2021.

4 Laryngoscope, 2021.Retraction „Effects of astragalus polysaccharide on apoptosis of myocardial microvascular endothelial cells in rats undergoing hypoxia/reoxygenation by mediation of the PI3K/Akt/eNOS signaling pathway,“ by Qingling Zhou, Guowei Meng, Fei Teng, Qiang Sun, Yongshan Zhang, J Cell Biochem. 2018; 806-816 The above article, published online on 28 June 2017 in Wiley Online Library (https//onlinelibrary.wiley.com/doi/10.1002/jcb.26243) has been retracted by agreement between the the journal’s Editor in Chief, Prof. Dr. Christian Behl, and Wiley Periodicals LLC. The retraction has been agreed following an investigation based on allegations raised by a third party. A detailed investigation revealed that several image elements of the experimental data were published elsewhere in a different scientific contest. Thus, the editors consider the conclusions of this article to be invalid.Retraction „Activation of the Nrf2-ARE Signaling Pathway Prevents Hyperphosphatemia-Induced Vascular Calcification by Inducing Autophagy in Renal Vascular Smooth Muscle Cells,“ by Li Yao, Jian Wang, Bin-Yao Tian, Tian-Hua Xu, Zi-Tong Sheng, J Cell Biochem. 2017; 4708-4715 The above article, published online on 17 May 2017 in Wiley Online Library (https//onlinelibrary.wiley.com/doi/10.1002/jcb.26137) has been retracted by agreement between the the journal’s Editor in Chief, Prof. Dr. Christian Behl, and Wiley Periodicals LLC. The retraction has been agreed following an investigation based on allegations raised by a third party. A detailed investigation revealed that several image elements of the experimental data were published elsewhere in a different scientific context. Thus, the editors consider the conclusions of this article to be invalid.There are over 50 SARS-CoV-2 candidate vaccines undergoing Phase II and III clinical trials. Several vaccines have been approved by regulatory authorities and rolled out for use in different countries. Due to concerns of potential teratogenicity or adverse effect on maternal physiology, pregnancy has been a specific exclusion criterion for most vaccine trials with only two trials not excluding pregnant women. Thus, other than limited animal studies, gradually emerging development and reproductive toxicity data, and observational data from vaccine registries, there is a paucity of reliable information to guide recommendations for the safe vaccination of pregnant women. Pregnancy is a risk factor for severe COVID-19, especially in women with comorbidities, resulting in increased rates of preterm birth and maternal morbidity. We discuss the major SARS-CoV-2 vaccines, their mechanisms of action, efficacy, safety profile and possible benefits to the maternal-fetal dyad to create a rational approach towards maternal vaccination while anticipating and mitigating vaccine-related complications. Pregnant women with high exposure risks or co-morbidities predisposing to severe COVID-19 infection should be prioritised for vaccination. Those with risk factors for adverse effects should be counselled accordingly. It is essential to support patient autonomy by shared decision-making involving a risk-benefit discussion with the pregnant woman.Eukaryotic cells employ three SMC (structural maintenance of chromosomes) complexes to control DNA folding and topology. The Smc5/6 complex plays roles in DNA repair and in preventing the accumulation of deleterious DNA junctions. To elucidate how specific features of Smc5/6 govern these functions, we reconstituted the yeast holo-complex. We found that the Nse5/6 sub-complex strongly inhibited the Smc5/6 ATPase by preventing productive ATP binding. This inhibition was relieved by plasmid DNA binding but not by short linear DNA, while opposing effects were observed without Nse5/6. We uncovered two binding sites for Nse5/6 on Smc5/6, based on an Nse5/6 crystal structure and cross-linking mass spectrometry data. One binding site is located at the Smc5/6 arms and one at the heads, the latter likely exerting inhibitory effects on ATP hydrolysis. Cysteine cross-linking demonstrated that the interaction with Nse5/6 anchored the ATPase domains in a non-productive state, which was destabilized by ATP and DNA. Under similar conditions, the Nse4/3/1 module detached from the ATPase. Altogether, we show how DNA substrate selection is modulated by direct inhibition of the Smc5/6 ATPase by Nse5/6.Retraction „MicroRNA-300 promotes apoptosis and inhibits proliferation, migration, invasion and epithelial-mesenchymal transition via the Wnt/β-catenin signaling pathway by targeting CUL4B in pancreatic cancer cells,“ by Jia-Qiang Zhang, Shi Chen, Jiang-Ning Gu, Yi Zhu, Qian Zhan, Dong-Feng Cheng, Hao Chen, Xia-Xing Deng, Bai-Yong Shen, Cheng-Hong Peng, J Cell Biochem. 2018; 1027-1040 The above article, published online on 07 July 2017 in Wiley Online Library (https//onlinelibrary.wiley.com/doi/10.1002/jcb.26270) has been retracted by agreement between the the journal’s Editor in Chief, Prof. Dr. Christian Behl, and Wiley Periodicals LLC. The retraction has been agreed following an investigation based on allegations raised by a third party. A detailed investigation revealed that several image elements of the experimental data were published elsewhere in a different scientific context. Thus, the editors consider the conclusions of this article to be invalid.Retraction „Inhibition of SNK-SPAR signaling pathway promotes the restoration of motor function in a rat model of ischemic stroke,“ by Qing-Yu Fan, Jing-Jie Liu, Gui-Lian Zhang, Hai-Qin Wu, Ru Zhang, Shu-Qin Zhan, Na Liu, J Cell Biochem. 2018; 1093-1110 The above article, published online on 11 July 2017 in Wiley Online Library (https//onlinelibrary.wiley.com/doi/10.1002/jcb.26278) has been retracted by agreement between the the journal’s Editor in Chief, Prof. Dr. Christian Behl, and Wiley Periodicals LLC. Alflutinib mouse The retraction has been agreed following an investigation based on allegations raised by a third party. A detailed investigation revealed that several image elements of the experimental data were published elsewhere in a different scientific context. Thus, the editors consider the conclusions of this article to be invalid.Retraction „microRNA-145-3p inhibits non-small cell lung cancer cell migration and invasion by targeting PDK1 via the mTOR signaling pathway,“ by Gui-Min Chen, A-Juan Zheng, Jing Cai, Ping Han, Hong-Bo Ji, Le-Le Wang, J Cell Biochem. 2018; 885-895 The above article, published online on 29 June 2017 in Wiley Online Library (https//onlinelibrary.wiley.com/doi/10.1002/jcb.26252) has been retracted by agreement between the the journal’s Editor in Chief, Prof. Dr. Christian Behl, and Wiley Periodicals LLC. The retraction has been agreed following an investigation based on allegations raised by a third party. A detailed investigation revealed that several image elements of the experimental data were published elsewhere in a different scientific context. Thus, the editors consider the conclusions of this article to be invalid.Retraction „MicroRNA-30d preserves pancreatic islet β-cell function through negative regulation of the JNK signaling pathway via SOCS3 in mice with streptozotocin-induced diabetes mellitus,“ by Shan Wang, Xin Wen, Xin-Rui Han, Yong-Jian Wang, Min Shen, Shao-Hua Fan, Juan Zhuang, Wei Xu, Zi-Feng Zhang, Qun Shan, Meng-Qiu Li, Bin Hu, Chun-Hui Sun, Dong-Mei Wu, Jun Lu, Yuan-Lin Zheng, J Cell Physiol. 2018; 7343-7355 The above article, published online on 16 April 2018 in Wiley Online Library (https//onlinelibrary.wiley.com/doi/10.1002/jcp.26569) has been retracted by agreement between the journal’s Editor in Chief, Prof. Dr. Gregg Fields, and Wiley Periodicals LLC. The retraction has been agreed following an investigation based on allegations raised by a third party. A detailed investigation revealed that several image elements of the experimental data were published elsewhere in a different scientific context. Thus, the editors consider the conclusions of this article to be invalid.Retraction „Protective effects of microRNA-431 against cerebral ischemia-reperfusion injury in rats by targeting the Rho/Rho-kinase signaling pathway,“ by Xin-Rui Han, Xin Wen, Yong-Jian Wang, Shan Wang, Min Shen, Zi-Feng Zhang, Shao-Hua Fan, Qun Shan, Liang Wang, Meng-Qiu Li, Bin Hu, Chun-Hui Sun, Dong-Mei Wu, Jun Lu, Yuan-Lin Zheng, J Cell Physiol. 2018; 5895-5907 The above article, published online on 11 December 2017 in Wiley Online Library (https//onlinelibrary.wiley.com/doi/10.1002/jcp.26394) has been retracted by agreement between the journal’s Editor in Chief, Prof. Dr. Gregg Fields, and Wiley Periodicals LLC. The retraction has been agreed following an investigation based on allegations raised by a third party. A detailed investigation revealed that several image elements of the experimental data were published elsewhere in a different scientific context. Thus, the editors consider the conclusions of this article to be invalid.The aim of this study is to explore how peer support workers (individuals with similar lived experiences employed to provide support) conceptualize change work with young people experiencing homelessness. The present study used participatory qualitative methods, including semistructured interviews and journaling with peer support workers and program supervisors and administrators, to understand how peers understand change work with young people experiencing homelessness. This study found that peers center self-directed growth among young people experiencing homelessness, rather than change that prioritizes meeting program-directed outcomes such as obtaining housing or gaining employment. Peer relationships invite possibility and create containers of hope when supporting young people experiencing homelessness, regardless of their paths. Lastly, peers recognize that growth happens in seasons, and embrace such seasons as checkpoints on youths‘ journeys. Such findings may guide service providers beginning peer programming or those considering models for engaging young people experiencing homelessness in relationship-supported growth.