s, whereas the VDR FokI polymorphism was correlated with SLE in African populations. But there was no association between the VDR TaqI polymorphism and SLE susceptibility in our analysis.

This study aimed to evaluate the effects of dentifrices with different fluoride content on color change of restorative materials commonly used in pediatric dentistry.

Three restorative materials (glass hybrid [Equia Forte (EF)], glass carbomer [GCP Glass Fill (GCP)] and compomer [Dyract XP (DXP)]) were used to prepare 120 disc shaped specimens by using a Teflon ring. Four dentifrice groups were created as Sodium Fluoride (NaF), Amine Fluoride (AmF), Stannous Fluoride (SnF2) and no-fluoride (n=40). Simulated tooth brushing was performed for each specimen by applying 6720 strokes for 6 months. Color changes [CIEDE2000 (ΔThe imaging of nitric oxide (NO) and its donors is crucial to explore NO-related physiological and pathological processes. In this work, we demonstrate the use of Cu-based metal-organic frameworks (Cu-MOFs) as nanoprobes for NO detection and as a catalyst for the generation of NO from the biologically occurring substrate, S-nitrosothiols (RSNOs). The paramagnetic Cu2+ in the MOFs could quench the luminescence of triphenylamine; Cu-MOFs only exhibited weak emission at 450 nm. Upon the addition of NO, the paramagnetic Cu2+ was reduced to diamagnetic Cu+, and thus the luminescence was recovered directly. Cu-MOFs exhibited high selectivity for other species in the reaction system, including NO2-, H2O2, AA, NO3- and 1O2. More significantly, the Cu+ can react with s-nitrosoglutathione (GSNO), s-nitrosocysteine (CysNO), and s-nitrosocysteamine (CysamNO) to generate NO and then oxidize to Cu2+-MOFs with quenched luminescence, respectively, and thus the catalysis is inhibited, noted as a self-controlled process. The Cu-MOFs catalyst was confirmed by powder X-ray diffraction to remain structurally intact in aqueous environments. The Cu-MOFs have been successfully employed in the biological imaging of NO in living cells. The bifunctional MOFs could offer a novel platform for the real-time monitoring of NO species, provide potential for exploiting NO in cancer therapy and improve the methodologies to elucidate the NO-related biological processes.We report a wire-shaped bifunctional oxygen photoelectrode by integrating Li-doped TiO2 nanotubes and Pt nanoclusters. Conductive nanoshells have been identified at the lithiated interface of Pt/TiO2, which facilitates the performance of oxygen catalysis. Thus, the assembled Zn-air micro-battery with solar-assisted charging greatly improves the voltage efficiency compared with the conventional state-of-the-art catalyst as the air electrode.[This corrects the article DOI 10.1039/D1RA00637A.].[This corrects the article DOI 10.1016/j.rcsop.2021.100007.].Data driven respiratory gating (DDG) in positron emission tomography (PET) imaging extracts respiratory waveforms from the acquired PET data obviating the need for dedicated external devices. DDG performance, however, degrades with decreasing detected number of coincidence counts. In this paper, we assess the clinical impact of reducing injected activity on a new DDG algorithm designed for PET data acquired with continuous bed motion (CBM_DDG) by evaluating CBM_DDG waveforms, tumor quantification, and physician’s perception of motion blur in resultant images. Forty patients were imaged on a Siemens mCT scanner in CBM mode. Reduced injected activity was simulated by generating list mode datasets with 50% and 25% of the original data (100%). CBM_DDG waveforms were compared to that of the original data over the range between the aortic arch and the center of the right kidney using the Pearson correlation coefficient (PCC). Tumor quantification was assessed by comparing the maximum standardized uptake value (SUVmax) and peak SUV (SUVpeak) of reconstructed images from the various list mode datasets using elastic motion deblurring (EMDB) reconstruction. Perceived motion blur was assessed by three radiologists of one lesion per patient on a continuous scale from no motion blur (0) to significant motion blur (3). The mean PCC of the 50% and 25% dataset waveforms was 0.74 ± 0.18 and 0.59 ± 0.25, respectively. In comparison to the 100% datasets, the mean SUVmax increased by 2.25% (p = 0.11) for the 50% datasets and by 3.91% (p = 0.16) for the 25% datasets, while SUVpeak changes were within ±0.25%. Radiologist evaluations of motion blur showed negligible changes with average values of 0.21, 0.3, and 0.28 for the 100%, 50%, and 25% datasets. Decreased injected activities degrades the resultant CBM_DDG respiratory waveforms; however this decrease has minimal impact on quantification and perceived image motion blur.[This retracts the article DOI 10.1039/C9RA00016J.].[This retracts the article DOI 10.1039/D0RA04249H.].[This corrects the article DOI 10.1039/D1RA02100A.].

Insertable cardiac monitors (ICMs) are increasingly used to evaluate the atrial fibrillation (AF) burden after catheter ablation of AF. GI254023X order BioMonitor III (BM3) is an ICM with a long sensing vector, which enhances sensing capabilities. The AF detection algorithm of the BM3 is based on R-R interval variability.

To evaluate the performance of the AF detection algorithm of BM3 in patients before and after catheter ablation of AF using simultaneous Holter recordings.

In this prospective study, we enrolled patients scheduled for catheter ablation of paroxysmal or persistent AF. After BM3 implantation, patients had a 4 days Holter registration before and 3 months after ablation. All true AF episodes ≥2 min on the Holter were annotated and matched with BM3 detected AF detections.

Thirty-one patients were enrolled (mean age 60 ± 8, 74% male, 68% paroxysmal AF). Fifty-six Holter registrations were performed in 30 patients. Twelve patients demonstrated at least one true AF episode with a total AF duration of 570h. The AF burden accuracy of BM3 before catheter ablation was 99.6%, with a duration sensitivity of 98.6% and a duration specificity of 99.9%. The AF burden accuracy of BM3 after catheter ablation was 99.8%, with a duration sensitivity of 90.2% and a duration specificity of 99.9%. Overall, the AF burden detected on the Holter and BM3 demonstrated a high Pearson correlation coefficient of 0.996.

BM3 accurately detects AF burden in patients before and after catheter ablation of AF.

BM3 accurately detects AF burden in patients before and after catheter ablation of AF.The COVID-19 global pandemic and high mortality rates necessitate the development of diagnostic and prognostic tools, as well as expanding testing capacity. Existing methods for detecting and characterizing SARS-CoV-2 infection are typically based on viral genome detection or measuring COVID-19-specific antibody levels. Despite their value, these methods are unable to predict disease outcomes in patients. Given the critical role of innate immune cells, particularly natural killer (NK) cells, in antiviral defense, this study sought to determine the prognostic value of serum secretory MHC class I polypeptide-related sequence A (sMICA) levels as an essential ligand for the NKG2D receptor, the master regulator of NK cell development and responsiveness. Serum MICA levels were measured by ELISA assay. Sera (n = 60) from SARS-CoV-2 positive patients were collected, and disease severity was determined using clinical criteria. The patient group included 30 patients with mild disease and 30 severely ill patients, as well as 30 healthy controls. Our findings revealed that serum MICA levels were significantly higher in patients than in controls, especially in cases with severe complications (P  less then  .0001). Higher serum MICA levels may be associated with respiratory failure in COVID-19 and may serve as a marker of clinical severity in patients infected with SARS-CoV-2, particularly when clinical manifestations are insufficient to make a confident prediction.

To compare the prevalence of adverse events related to vasoactive drug infusions administered via a peripheral venous catheter versus a central venous or intraosseous catheter.

Retrospective observational study.

A pediatric critical care transport team, and the PICUs and regional hospitals within the North Thames and East Anglia regions of the United Kingdom.

Children (up to 18 yr old) transported by the Children’s Acute Transport Service receiving an infusion of a vasoactive drug (epinephrine, dobutamine, dopamine, norepinephrine, and vasopressin).

None.

The medical records of all children transported between April 2017 and May 2020 receiving a vasoactive drug infusion were reviewed and cross-referenced with the service critical incident database. The outcome measure was anatomic catheter-related adverse events (including extravasation) reported during transport or in the first 24 hours on the PICU. During the study period, the service undertook 3,836 transports. Vasoactive drugs were administered during 558 patient transports (14.5%). During 198 of 558 transports (35.5%), vasoactive drugs were administered via a peripheral venous catheter, with seven of 198 (3.5%) adverse events. One extravasation event resulted in tissue necrosis. The median time to injury after the infusion was commenced was 60 minutes (interquartile range, 30-60 min). During 360 of 558 transports (64.5%), vasoactive infusions were administered by central venous or intraosseous catheter, with nine of 360 (2.5%) adverse events.

During pediatric critical care transport, we did not find a difference in prevalence of adverse events following the administration of vasoactive drugs via peripheral venous catheters or via central venous and intraosseous catheters.

During pediatric critical care transport, we did not find a difference in prevalence of adverse events following the administration of vasoactive drugs via peripheral venous catheters or via central venous and intraosseous catheters.

Sepsis awareness and understanding are important aspects of prevention, recognition, and clinical management of sepsis. We conducted a scoping review to identify and map the literature related to sepsis awareness, general knowledge, and information-seeking behaviors with a goal to inform future sepsis research and knowledge translation campaigns.

Scoping review.

Using Arksey and O’Malley’s methodological framework, we conducted a systematic search on May 3, 2021, across four databases (MEDLINE, EMBASE, CINAHL, and Education Research Complete). Title/abstract and full-text screening was done in duplicate. One researcher extracted the data for each included article, and a second researcher checked data accuracy. The protocol was registered on Open Science Framework ( https//doi.org/10.17605/OSF.IO/YX7AU ).

Articles related to sepsis awareness, knowledge, and information seeking behaviors among patients, public, and healthcare professionals.

None.

Of 5,927 unique studies, 80 reported on patient ( n =, and healthcare professional awareness and knowledge of sepsis vary globally. Future research may benefit from a consistent definition as well as country-specific data to support targeted public awareness campaigns.

Patient, public, and healthcare professional awareness and knowledge of sepsis vary globally. Future research may benefit from a consistent definition as well as country-specific data to support targeted public awareness campaigns.